BDBM318857 (R)-6-(4-chlorophenyl)-3-cyclopropyl-5-(3,8-dimethyl-[1,2,4]triazolo[4,3-a]pyridin-6-yl)-1-((R)-3,3,3-trifluoro-2-hydroxypropyl)-5,6-dihvdropyrrolo[3,4-c]pyrazol-4(1H)-one::US9624247, Example 19

SMILES Cc1nnc2c(C)cc(cn12)N1[C@@H](c2c(C1=O)c(nn2C[C@@H](O)C(F)(F)F)C1CC1)c1ccc(Cl)cc1

InChI Key InChIKey=NCLGWTFZOQZNIS-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 318857   

TargetBromodomain-containing protein 4(Human)
Novartis

US Patent
LigandPNGBDBM318857(US9624247, Example 19 | (R)-6-(4-chlorophenyl)-3-c...)
Affinity DataIC50: 23nMAssay Description:All assays were performed in 384 well microtiter plates. Each assay plate contained 8-point serial dilutions for 40 test compounds, plus 16 high- and...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/15/2019
Entry Details
US Patent

TargetBromodomain-containing protein 3(Human)
Novartis

US Patent
LigandPNGBDBM318857(US9624247, Example 19 | (R)-6-(4-chlorophenyl)-3-c...)
Affinity DataIC50: 25nMAssay Description:All assays were performed in 384 well microtiter plates. Each assay plate contained 8-point serial dilutions for 40 test compounds, plus 16 high- and...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/15/2019
Entry Details
US Patent

TargetBromodomain-containing protein 2(Human)
Novartis

US Patent
LigandPNGBDBM318857(US9624247, Example 19 | (R)-6-(4-chlorophenyl)-3-c...)
Affinity DataIC50: 29nMAssay Description:All assays were performed in 384 well microtiter plates. Each assay plate contained 8-point serial dilutions for 40 test compounds, plus 16 high- and...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/15/2019
Entry Details
US Patent

TargetCREB-binding protein(Human)
Novartis

US Patent
LigandPNGBDBM318857(US9624247, Example 19 | (R)-6-(4-chlorophenyl)-3-c...)
Affinity DataIC50: 9.40E+3nMAssay Description:In order to assess bromodomain selectivity, we set up a binding assay using the bromodomain encoded by the CREBBP gene. Compounds were tested in the ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/15/2019
Entry Details
US Patent