BDBM318863 US9624247, Example 27::tert-butyl (6-(6-(4-chlorophenyl)-3-cyclopropyl-1-methyl-4-oxopyrrolo[3,4-c]pyrazol-5(1H,4H,6H)-yl)-3-methyl-[1,2,4]triazolo[4,3-a]pyridin-8-yl)carbamate

SMILES Cc1nnc2c(NC(=O)OC(C)(C)C)cc(cn12)N1C(c2c(C1=O)c(nn2C)C1CC1)c1ccc(Cl)cc1

InChI Key InChIKey=OYDMPDMTZYTSSQ-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 318863   

TargetBromodomain-containing protein 4(Human)
Novartis

US Patent
LigandChemical structure of BindingDB Monomer ID 318863BDBM318863(US9624247, Example 27 | tert-butyl (6-(6-(4-chloro...)
Affinity DataIC50: 36nMAssay Description:All assays were performed in 384 well microtiter plates. Each assay plate contained 8-point serial dilutions for 40 test compounds, plus 16 high- and...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/15/2019
Entry Details
US Patent

TargetBromodomain-containing protein 2(Human)
Novartis

US Patent
LigandChemical structure of BindingDB Monomer ID 318863BDBM318863(US9624247, Example 27 | tert-butyl (6-(6-(4-chloro...)
Affinity DataIC50: 47nMAssay Description:All assays were performed in 384 well microtiter plates. Each assay plate contained 8-point serial dilutions for 40 test compounds, plus 16 high- and...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/15/2019
Entry Details
US Patent

TargetBromodomain-containing protein 3(Human)
Novartis

US Patent
LigandChemical structure of BindingDB Monomer ID 318863BDBM318863(US9624247, Example 27 | tert-butyl (6-(6-(4-chloro...)
Affinity DataIC50: 65nMAssay Description:All assays were performed in 384 well microtiter plates. Each assay plate contained 8-point serial dilutions for 40 test compounds, plus 16 high- and...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/15/2019
Entry Details
US Patent

TargetCREB-binding protein(Human)
Novartis

US Patent
LigandChemical structure of BindingDB Monomer ID 318863BDBM318863(US9624247, Example 27 | tert-butyl (6-(6-(4-chloro...)
Affinity DataIC50: 8.10E+3nMAssay Description:In order to assess bromodomain selectivity, we set up a binding assay using the bromodomain encoded by the CREBBP gene. Compounds were tested in the ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/15/2019
Entry Details
US Patent