BDBM31901 Pyrano[3,2-c]quinoline-6-chlorotacrine hybrid, 26.2HCl

SMILES Clc1ccc2c(NCCCCCCCNC(=O)CCc3ccc4nc(-c5ccccc5)c5CCCOc5c4c3)c3CCCCc3nc2c1

InChI Key InChIKey=WZSXQVUTYDCZRO-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 31901   

TargetAcetylcholinesterase(Homo sapiens (Human))
Universitat De Barcelona

LigandPNGBDBM31901(Pyrano[3,2-c]quinoline-6-chlorotacrine hybrid, 26....)
Affinity DataIC50:  14.4nMpH: 8.0 T: 2°CAssay Description:AChE inhibitory activity was evaluated spectrophotometrically by the method of Ellman, using AChE from bovine or human erythrocytes and acetylthiocho...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Homo sapiens (Human))
Universitat De Barcelona

LigandPNGBDBM31901(Pyrano[3,2-c]quinoline-6-chlorotacrine hybrid, 26....)
Affinity DataIC50:  11nMAssay Description:Inhibition of AChE (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetCholinesterase(Homo sapiens (Human))
Universitat De Barcelona

LigandPNGBDBM31901(Pyrano[3,2-c]quinoline-6-chlorotacrine hybrid, 26....)
Affinity DataIC50:  234nMAssay Description:BChE inhibitory activity was evaluated spectrophotometrically by the method of Ellman, using BChE from human serum and butyrylthiocholine as substrat...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Bos taurus (bovine))
Universitat De Barcelona

LigandPNGBDBM31901(Pyrano[3,2-c]quinoline-6-chlorotacrine hybrid, 26....)
Affinity DataIC50:  29.9nMpH: 8.0 T: 2°CAssay Description:AChE inhibitory activity was evaluated spectrophotometrically by the method of Ellman, using AChE from bovine or human erythrocytes and acetylthiocho...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed