BDBM319442 N-[(cyclopropyl- carbamoyl) methyl]-2- (dimethyl- sulfamoyl)-2-[4- fluoro-6-(2- methyl-1-oxo-1,2- dihydro- isoquinolin-6-yl)- 1,3-benzothiazol- 2-yl]acetamide::US10173991, Example 493

SMILES CN(C)S(=O)(=O)C(C(=O)NCC(=O)NC1CC1)c1nc2c(F)cc(cc2s1)-c1ccc2c(ccn(C)c2=O)c1

InChI Key InChIKey=BCZXIOVYWXTVJG-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 319442   

TargetEndothelial lipase(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM319442(N-[(cyclopropyl- carbamoyl) methyl]-2- (dimethyl- ...)
Affinity DataIC50: 1nMAssay Description:Endothelial lipase (EL) and hepatic lipase (HL) activities were measured using a fluorescent substrate, A10070, (Invitrogen, CA) doped into an artifi...More data for this Ligand-Target Pair
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Date in BDB:
5/15/2019
Entry Details
US Patent