BDBM319524 2-{6-[4-(5-amino- 4-cyano-1H- pyrazol-1-yl) phenyl]-5-fluoro- 1,3-benzothiazol- 2-yl}-N- [(cyclopropyl- carbamoyl) methyl]-2-(2- methoxyethane- sulfonyl)acetamide::US10173991, Example 585

SMILES COCCS(=O)(=O)C(C(=O)NCC(=O)NC1CC1)c1nc2cc(F)c(cc2s1)-c1ccc(cc1)-n1ncc([N+]#[C-])c1N

InChI Key InChIKey=AQODMBAMVOEBDL-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 319524   

TargetEndothelial lipase(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM319524(2-{6-[4-(5-amino- 4-cyano-1H- pyrazol-1-yl) phenyl...)
Affinity DataIC50: 1nMAssay Description:Endothelial lipase (EL) and hepatic lipase (HL) activities were measured using a fluorescent substrate, A10070, (Invitrogen, CA) doped into an artifi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/15/2019
Entry Details
US Patent