BDBM319525 5-amino-1-{4-[2- ({[(cyclopropyl- carbamoyl)methyl] carbamoyl}(2- methoxyethane- sulfonyl)methyl)- 5-fluoro-1,3- benzothiazol- 6-yl]phenyl}-1H- pyrazole-4- carboxamide::US10173991, Example 586

SMILES COCCS(=O)(=O)C(C(=O)NCC(=O)NC1CC1)c1nc2cc(F)c(cc2s1)-c1ccc(cc1)-n1ncc(C(N)=O)c1N

InChI Key InChIKey=PMDJJUWSCIFWGR-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 319525   

TargetEndothelial lipase(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM319525(5-amino-1-{4-[2- ({[(cyclopropyl- carbamoyl)methyl...)
Affinity DataIC50: 1nMAssay Description:Endothelial lipase (EL) and hepatic lipase (HL) activities were measured using a fluorescent substrate, A10070, (Invitrogen, CA) doped into an artifi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/15/2019
Entry Details
US Patent