BDBM320222 3-{[(3S)-4- methylmorpholin-3- yl]methoxy}-5-(5- methyl-1,3-thiazol- 2-yl)-N-{(1R)-1-[6- (trifluoromethyl) pyridazin-3-yl] ethyl}benzamide::US10174016, Example 389::US10202369, Example 389::US10472354, Example 389

SMILES C[C@@H](NC(=O)c1cc(OC[C@@H]2COCCN2C)cc(c1)-c1ncc(C)s1)c1ccc(nn1)C(F)(F)F

InChI Key InChIKey=SOWWCICJAYGBSY-UHFFFAOYSA-N

Data  8 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 320222   

TargetP2X purinoceptor 3(Human)
Bayer Aktiengesellschaft

US Patent
LigandChemical structure of BindingDB Monomer ID 320222BDBM320222(3-{[(3S)-4- methylmorpholin-3- yl]methoxy}-5-(5- m...)
Affinity DataIC50: 18nMAssay Description:A fluorescent imaging plate reader (FLEX/FLIPR station; Molecular Devices) was used to monitor intracellular calcium levels using the calcium-chelati...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2019
Entry Details
US Patent

TargetP2X purinoceptor 3(Human)
Bayer Aktiengesellschaft

US Patent
LigandChemical structure of BindingDB Monomer ID 320222BDBM320222(3-{[(3S)-4- methylmorpholin-3- yl]methoxy}-5-(5- m...)
Affinity DataIC50: 18nMAssay Description:A fluorescent imaging plate reader (FLEX/FLIPR station; Molecular Devices) was used to monitor intracellular calcium levels using the calcium-chelati...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/15/2019
Entry Details
US Patent

TargetP2X purinoceptor 3(Human)
Bayer Aktiengesellschaft

US Patent
LigandChemical structure of BindingDB Monomer ID 320222BDBM320222(3-{[(3S)-4- methylmorpholin-3- yl]methoxy}-5-(5- m...)
Affinity DataIC50: 18nMAssay Description:A fluorescent imaging plate reader (FILEX/FLIPR station; Molecular Devices) was used to monitor intracellular calcium levels using the calcium-chelat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/14/2020
Entry Details
US Patent

TargetP2X purinoceptor 3(Human)
Bayer Aktiengesellschaft

US Patent
LigandChemical structure of BindingDB Monomer ID 320222BDBM320222(3-{[(3S)-4- methylmorpholin-3- yl]methoxy}-5-(5- m...)
Affinity DataIC50: 18nMAssay Description:A fluorescent imaging plate reader (FLEX/FLIPR station; Molecular Devices) was used to monitor intracellular calcium levels using the calcium-chelati...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/16/2019
Entry Details
US Patent

TargetP2X purinoceptor 2/3(Human)
Bayer Aktiengesellschaft

US Patent
LigandChemical structure of BindingDB Monomer ID 320222BDBM320222(3-{[(3S)-4- methylmorpholin-3- yl]methoxy}-5-(5- m...)
Affinity DataIC50: 1.61E+3nMAssay Description:A fluorescent imaging plate reader (FLEX/FLIPR station; Molecular Devices) was used to monitor intracellular calcium levels using the calcium-chelati...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2019
Entry Details
US Patent

TargetP2X purinoceptor 2(Human)
Beyer Aktiengesellschaft

US Patent
LigandChemical structure of BindingDB Monomer ID 320222BDBM320222(3-{[(3S)-4- methylmorpholin-3- yl]methoxy}-5-(5- m...)
Affinity DataIC50: 1.61E+3nMAssay Description:A fluorescent imaging plate reader (FLEX/FLIPR station; Molecular Devices) was used to monitor intracellular calcium levels using the calcium-chelati...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/15/2019
Entry Details
US Patent

TargetP2X purinoceptor 2(Human)
Beyer Aktiengesellschaft

US Patent
LigandChemical structure of BindingDB Monomer ID 320222BDBM320222(3-{[(3S)-4- methylmorpholin-3- yl]methoxy}-5-(5- m...)
Affinity DataIC50: 1.61E+3nMAssay Description:A fluorescent imaging plate reader (FLEX/FLIPR station; Molecular Devices) was used to monitor intracellular calcium levels using the calcium-chelati...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/16/2019
Entry Details
US Patent

TargetP2X purinoceptor 2/3(Human)
Bayer Aktiengesellschaft

US Patent
LigandChemical structure of BindingDB Monomer ID 320222BDBM320222(3-{[(3S)-4- methylmorpholin-3- yl]methoxy}-5-(5- m...)
Affinity DataIC50: 1.61E+3nMAssay Description:A fluorescent imaging plate reader (FILEX/FLIPR station; Molecular Devices) was used to monitor intracellular calcium levels using the calcium-chelat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/14/2020
Entry Details
US Patent