BDBM321127 (S)-methyl (8-((2-amino-2,4-dimethylpentyl)oxy)-1-chloro-9-fluoro-6H-isochromeno[3,4-c]pyridin-2-yl)carbamate::US10174044, Example 58

SMILES COC(=O)Nc1ncc2OCc3cc(OC[C@@](C)(N)CC(C)C)c(F)cc3-c2c1Cl

InChI Key InChIKey=XRIRBHKYKLELPQ-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 321127   

TargetAP2-associated protein kinase 1(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM321127((S)-methyl (8-((2-amino-2,4-dimethylpentyl)oxy)-1-...)
Affinity DataIC50: 18nMAssay Description:The assays were performed in U-bottom 384-well plates. The final assay volume was 30 μl prepared from 15 μl additions of enzyme and substra...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/16/2019
Entry Details
US Patent