BDBM321178 US10179123, Example 2-3-2::methyl 2-[4-(trifluoromethoxy)benzyl]-1-[(cis)-3,3,5-trimethylcyclohexyl]-1H-benzimidazole-5-carboxylate, Enantiomer B

SMILES COC(=O)c1ccc2n([C@@H]3C[C@H](C)CC(C)(C)C3)c(Cc3ccc(OC(F)(F)F)cc3)nc2c1

InChI Key InChIKey=FLKIGLHBPCYBSL-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 321178   

TargetIsocitrate dehydrogenase [NADP] cytoplasmic [R132H](Human)
Bayer Pharma Aktiengesellschaft

US Patent
LigandPNGBDBM321178(US10179123, Example 2-3-2 | methyl 2-[4-(trifluoro...)
Affinity DataIC50: 610nMAssay Description:mIDH1 catalyzes the NADPH-dependent reduction of alpha-ketoglutarate (α-KG) to (2R)-2-hydroxyglutarate (2-HG). NADPH consumption was measured by...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/16/2019
Entry Details
US Patent