BDBM321338 US10179791, Compound 321::US10807991, Compound 321

SMILES OC(=O)CCN1CCCC2(COc3cc(OCc4c(Cl)cccc4Cl)ccc23)C1

InChI Key InChIKey=CGLQYKZDFSJSJB-UHFFFAOYSA-N

Data  9 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 321338   

TargetSphingosine 1-phosphate receptor 5(Human)
Abbvie

US Patent
LigandPNGBDBM321338(US10179791, Compound 321 | US10807991, Compound 32...)
Affinity DataEC50:  79.4nMAssay Description:The CHO-human-S1P5-Aeqorin assay was bought from Euroscreen, Brussels (Euroscreen, Technical dossier, Human Lysophospholid S1P5 (Edg8) receptor, DNA ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/16/2019
Entry Details
US Patent

TargetSphingosine 1-phosphate receptor 5(Human)
Abbvie

US Patent
LigandPNGBDBM321338(US10179791, Compound 321 | US10807991, Compound 32...)
Affinity DataEC50:  79.4nMAssay Description:The CHO-human-S1P5-Aeqorin assay was bought from Euroscreen, Brussels (Euroscreen, Technical dossier, Human Lysophospholid S1P5 (Edg8) receptor, DNA ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2021
Entry Details
US Patent

TargetSphingosine 1-phosphate receptor 5(Human)
Abbvie

US Patent
LigandPNGBDBM321338(US10179791, Compound 321 | US10807991, Compound 32...)
Affinity DataEC50:  100nMAssay Description:Agonist activity at human S1P5 receptor expressed in CHO cells assessed as increase in calcium flux by aequorin-derived luminescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetSphingosine 1-phosphate receptor 3(Human)
Abbvie

US Patent
LigandPNGBDBM321338(US10179791, Compound 321 | US10807991, Compound 32...)
Affinity DataEC50: <1.00E+4nMAssay Description:The CHO-human-S1P3-Aeqorin assay (CHO/Gα16/AEQ/h-S1P3) was established at Solvay Pharmaceuticals. The plasmid DNA coding for the S1P3 receptor (...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/16/2019
Entry Details
US Patent

TargetSphingosine 1-phosphate receptor 3(Human)
Abbvie

US Patent
LigandPNGBDBM321338(US10179791, Compound 321 | US10807991, Compound 32...)
Affinity DataEC50: <1.00E+4nMAssay Description:Agonist activity at human S1P3 receptor expressed in CHO cells assessed as increase in calcium flux by aequorin-derived luminescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetSphingosine 1-phosphate receptor 3(Human)
Abbvie

US Patent
LigandPNGBDBM321338(US10179791, Compound 321 | US10807991, Compound 32...)
Affinity DataEC50: >1.00E+4nMAssay Description:The CHO-human-S1P3-Aeqorin assay (CHO/Gal6/AEQ/h-S1P3) was established at Solvay Pharmaceuticals. The plasmid DNA coding for the S1P3 receptor (acces...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2021
Entry Details
US Patent

LigandPNGBDBM321338(US10179791, Compound 321 | US10807991, Compound 32...)
Affinity DataEC50: <3.16E+4nMAssay Description:Agonist activity at human S1P1 receptor expressed in CHO cells assessed as increase in calcium flux by aequorin-derived luminescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
LigandPNGBDBM321338(US10179791, Compound 321 | US10807991, Compound 32...)
Affinity DataEC50: <3.16E+4nMAssay Description:The CHO-K1-human-S1P1-Aeqorin assay was bought from Euroscreen Fast, Brussels (Euroscreen, Technical dossier, Human S1P1 (Edg1) receptor, DNA clone a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/16/2019
Entry Details
US Patent

LigandPNGBDBM321338(US10179791, Compound 321 | US10807991, Compound 32...)
Affinity DataEC50: >3.16E+4nMAssay Description:The CHO-K1-human-S1P1-Aeqorin assay was bought from Euroscreen Fast, Brussels (Euroscreen, Technical dossier, Human S1P1 (Edg1) receptor, DNA clone a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/11/2021
Entry Details
US Patent