BDBM321532 US10183021, Compound I-369

SMILES OC(=O)[C@@H]1CCc2ccccc2[C@@H]1Nc1nc(ncc1F)-c1cc(-c2ccon2)n(Cc2ccccc2F)n1

InChI Key InChIKey=NDQVDMVEOJLWIP-UHFFFAOYSA-N

Data  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 321532   

TargetGuanylate cyclase soluble subunit alpha-1(Human)
Ironwood Pharmaceuticals

US Patent
LigandPNGBDBM321532(US10183021, Compound I-369)
Affinity DataEC50: <100nMAssay Description:Human embryonic kidney cells (HEK293), endogenously expressing soluble guanylate cyclase (sGC), were used to evaluate the activity of test compounds....More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/16/2019
Entry Details
US Patent