BDBM322567 US10183940, Example 20

SMILES Cn1nc(c2ccccc12)C(C)(C)NC(=O)c1ccnc2CNCCOc12

InChI Key InChIKey=BESJHHWUGXQXGG-UHFFFAOYSA-N

Data  5 KI  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 322567   

TargetSomatostatin receptor type 4(Human)
Boehringer Ingelheim International

US Patent
LigandPNGBDBM322567(US10183940, Example 20)
Affinity DataEC50:  17.5nMAssay Description:The activation of the SSTR4 receptor (Gi coupled) causes an inhibition of intracellular cAMP after stimulation with Forskolin, which can be quantifia...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/16/2019
Entry Details
US Patent

TargetSomatostatin receptor type 4(Human)
Boehringer Ingelheim International

US Patent
LigandPNGBDBM322567(US10183940, Example 20)
Affinity DataKi:  574nMAssay Description:Method description for binding assays with human Somatostatin receptors by use of CHO cell membranes expressing recombinant human SSTR1 or human SSTR...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/16/2019
Entry Details
US Patent

TargetSomatostatin receptor type 3(Human)
Boehringer Ingelheim International

US Patent
LigandPNGBDBM322567(US10183940, Example 20)
Affinity DataKi:  8.62E+3nMAssay Description:Method description for binding assays with human Somatostatin receptors by use of CHO cell membranes expressing recombinant human SSTR1 or human SSTR...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/16/2019
Entry Details
US Patent

TargetSomatostatin receptor type 1(Human)
Boehringer Ingelheim International

US Patent
LigandPNGBDBM322567(US10183940, Example 20)
Affinity DataKi:  9.45E+3nMAssay Description:Method description for binding assays with human Somatostatin receptors by use of CHO cell membranes expressing recombinant human SSTR1 or human SSTR...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/16/2019
Entry Details
US Patent

TargetSomatostatin receptor type 2(Human)
Boehringer Ingelheim International

US Patent
LigandPNGBDBM322567(US10183940, Example 20)
Affinity DataKi:  9.60E+3nMAssay Description:Method description for binding assays with human Somatostatin receptors by use of CHO cell membranes expressing recombinant human SSTR1 or human SSTR...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/16/2019
Entry Details
US Patent

TargetSomatostatin receptor type 5(Human)
Boehringer Ingelheim International

US Patent
LigandPNGBDBM322567(US10183940, Example 20)
Affinity DataKi:  9.75E+3nMAssay Description:Method description for binding assays with human Somatostatin receptors by use of CHO cell membranes expressing recombinant human SSTR1 or human SSTR...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/16/2019
Entry Details
US Patent