BDBM322733 2-(1-(5-((2-(4-(cyanomethyl)piperidin-1- yl)-5-oxo-5,6-dihydropyrimido[4,5- d]pyridazin-4-yl)amino)pyridin-2-yl) piperidin-4-yl)acetonitrile::US10183944, Example 103

SMILES O=c1[nH]ncc2nc(nc(Nc3ccc(nc3)N3CCC(CC#N)CC3)c12)N1CCC(C[N+]#[C-])CC1

InChI Key InChIKey=MSQMJPKCBNWJBU-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 322733   

TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Asana Biosciences

US Patent
LigandPNGBDBM322733(2-(1-(5-((2-(4-(cyanomethyl)piperidin-1- yl)-5-oxo...)
Affinity DataIC50: <10nMAssay Description:Two μL of 10% DMSO in blank, substrate control and positive control wells and 2 μL of test compound in test wells was added. Thirteen μ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Asana Biosciences

US Patent
LigandPNGBDBM322733(2-(1-(5-((2-(4-(cyanomethyl)piperidin-1- yl)-5-oxo...)
Affinity DataIC50: <10nMAssay Description:2.5 μL of 10% DMSO or compound in 10% DMSO was added to the wells in a 96 well V-bottom plate. Optimized concentration of in-house Syk enzyme (d...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent