BDBM322815 2-(1-(4-((4-(2-(4-hydroxy-4- methylpiperidin-1-yl)ethoxy)phenyl) amino)-5-oxo-5,6-dihydropyrimido[4,5- d]pyridazin-2-yl)piperidin-4- yl)acetonitrile::US10183944, Example 185

SMILES CC1(O)CCN(CCOc2ccc(Nc3nc(nc(C=N)c3C(N)=O)N3CCC(C[N+]#[C-])CC3)cc2)CC1

InChI Key InChIKey=DIEGSKARCJUTEK-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 322815   

TargetTyrosine-protein kinase SYK(Human)
Asana Biosciences

US Patent
LigandPNGBDBM322815(US10183944, Example 185 | 2-(1-(4-((4-(2-(4-hydrox...)
Affinity DataIC50: 10nMAssay Description:2.5 μL of 10% DMSO or compound in 10% DMSO was added to the wells in a 96 well V-bottom plate. Optimized concentration of in-house Syk enzyme (d...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/16/2019
Entry Details
US Patent

TargetTyrosine-protein kinase JAK2(Human)
Asana Biosciences

US Patent
LigandPNGBDBM322815(US10183944, Example 185 | 2-(1-(4-((4-(2-(4-hydrox...)
Affinity DataIC50: 50nMAssay Description:Two μL of 10% DMSO in blank, substrate control and positive control wells and 2 μL of test compound in test wells was added. Thirteen μ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/16/2019
Entry Details
US Patent