BDBM322837 2-(1-(4-((4-(4-(cyanomethyl)piperazin-1- yl)phenyl)amino)-5-oxo-5,6- dihydropyrimido[4,5-d]pyridazin-2-yl) piperidin-4-yl)acetonitrile::US10183944, Example 207

SMILES NC(=O)c1c(Nc2ccc(cc2)N2CCN(CC#N)CC2)nc(nc1C=N)N1CCC(C[N+]#[C-])CC1

InChI Key InChIKey=PCVWLJNMRSGOMU-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 322837   

TargetTyrosine-protein kinase SYK(Human)
Asana Biosciences

US Patent
LigandPNGBDBM322837(2-(1-(4-((4-(4-(cyanomethyl)piperazin-1- yl)phenyl...)
Affinity DataIC50: 10nMAssay Description:2.5 μL of 10% DMSO or compound in 10% DMSO was added to the wells in a 96 well V-bottom plate. Optimized concentration of in-house Syk enzyme (d...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/16/2019
Entry Details
US Patent

TargetTyrosine-protein kinase JAK2(Human)
Asana Biosciences

US Patent
LigandPNGBDBM322837(2-(1-(4-((4-(4-(cyanomethyl)piperazin-1- yl)phenyl...)
Affinity DataIC50: 10nMAssay Description:Two μL of 10% DMSO in blank, substrate control and positive control wells and 2 μL of test compound in test wells was added. Thirteen μ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/16/2019
Entry Details
US Patent