BDBM323769 4-{[(6-Bromo-3-methyl-1-oxido-2-phenylquinolin-4-yl)carbonyl]amino}-3-fluorobenzoic acid::US10189788, Example 49

SMILES Cc1c(C(=O)Nc2ccc(cc2F)C(O)=O)c2cc(Br)ccc2[n+]([O-])c1-c1ccccc1

InChI Key InChIKey=XFKQOUQPPQEIHL-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 323769   

TargetProstaglandin F2-alpha receptor(Human)
Bayer Pharma Aktiengesellschaft

US Patent
LigandPNGBDBM323769(4-{[(6-Bromo-3-methyl-1-oxido-2-phenylquinolin-4-y...)
Affinity DataIC50:  120nMAssay Description:For the characterization of test substances in respect of FP antagonism, PGF2α-induced calcium flux in FP-expressing CHEM1 cells (Millipore, HTS...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent

TargetProstaglandin F2-alpha receptor(Human)
Bayer Pharma Aktiengesellschaft

US Patent
LigandPNGBDBM323769(4-{[(6-Bromo-3-methyl-1-oxido-2-phenylquinolin-4-y...)
Affinity DataIC50:  120nMAssay Description:Antagonist activity at human FPR expressed in human Chem-1 cells assessed as inhibition of PGF2alpha-induced calcium flux preincubated for 10 mins fo...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Human)
Bayer

Curated by ChEMBL
LigandPNGBDBM323769(4-{[(6-Bromo-3-methyl-1-oxido-2-phenylquinolin-4-y...)
Affinity DataIC50: >2.00E+4nMAssay Description:Inhibition of CYP3A4 in human liver microsomes using midazolam as substrate incubated for 10 mins in presence of NADPH generating system by LC-MS/MS ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed