BDBM324327 (R)-5-(tert-butyl)-N-(8- (2-((5,6-dihydro-4H- pyrrolo[1,2-b]pyrazol-3- yl)amino)pyrimidin-4- yl)-2-(2-hydroxyethyl)- 2,3,4,5-tetrahydro-1H- benzo[c]azepin-5-yl)- 1,3,4-oxadiazole-2- carboxamide::US10189829, Compound 93::US10227341, Compound 93::US10961237, Compound 93::US11858926, Compound 93

SMILES CC(C)(C)c1nnc(o1)C(=O)N[C@@H]1CCN(CCO)Cc2cc(ccc12)-c1ccnc(Nc2cnn3CCCc23)n1

InChI Key InChIKey=DEPARKCHVHPYBC-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 324327   

TargetTyrosine-protein kinase BTK(Human)
Biogen Ma

US Patent
LigandPNGBDBM324327((R)-5-(tert-butyl)-N-(8- (2-((5,6-dihydro-4H- pyrr...)
Affinity DataIC50: 1nMAssay Description:The purpose of the BTK in vitro assay is to determine compound potency against BTK through the measurement of IC50. Compound inhibition is measured a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/25/2019
Entry Details
US Patent

TargetTyrosine-protein kinase BTK(Human)
Biogen Ma

US Patent
LigandPNGBDBM324327((R)-5-(tert-butyl)-N-(8- (2-((5,6-dihydro-4H- pyrr...)
Affinity DataIC50: 1nMAssay Description:The purpose of the BTK in vitro assay is to determine compound potency against BTK through the measurement of IC50. Compound inhibition is measured a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/4/2021
Entry Details
US Patent

TargetTyrosine-protein kinase BTK [14-552](Human)
Biogen Ma

US Patent
LigandPNGBDBM324327((R)-5-(tert-butyl)-N-(8- (2-((5,6-dihydro-4H- pyrr...)
Affinity DataIC50: 1nMAssay Description:The purpose of the BTK in vitro assay is to determine compound potency against BTK through the measurement of IC50. Compound inhibition is measured a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2024
Entry Details
US Patent

TargetTyrosine-protein kinase BTK(Human)
Biogen Ma

US Patent
LigandPNGBDBM324327((R)-5-(tert-butyl)-N-(8- (2-((5,6-dihydro-4H- pyrr...)
Affinity DataIC50: 505nMAssay Description:The purpose of the BTK in vitro assay is to determine compound potency against BTK through the measurement of IC50. Compound inhibition is measured a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2019
Entry Details
US Patent