BDBM324580 3-[[3-[2-[[1-[2-(4- methylpiperazin-1-yl)-2- oxo-ethyl]pyraol-4- yl]amino]- [1,2,4]triazolo[1,5-a] pyridin-8-yl]-3,8- diazabicyclo[3.2.1]octan- 8-yl]sulfonyl]benzonitrile::US10189836, Example 143

SMILES CN1CCN(CC1)C(=O)Cn1cc(Nc2nc3c(cccn3n2)N2CC3CCC(C2)N3S(=O)(=O)c2cccc(c2)C#N)cn1

InChI Key InChIKey=YHNOGRUFSRKFQZ-UHFFFAOYSA-N

Data  2 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 324580   

TargetTyrosine-protein kinase JAK1(Human)
Genentech

US Patent
LigandPNGBDBM324580(3-[[3-[2-[[1-[2-(4- methylpiperazin-1-yl)-2- oxo-e...)
Affinity DataKi:  0.5nMAssay Description:The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/26/2019
Entry Details
US Patent

TargetTyrosine-protein kinase JAK2(Human)
Genentech

US Patent
LigandPNGBDBM324580(3-[[3-[2-[[1-[2-(4- methylpiperazin-1-yl)-2- oxo-e...)
Affinity DataKi:  1.10nMAssay Description:The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/26/2019
Entry Details
US Patent