BDBM327854 2-[8-fluoro-2-[2- (hydroxymethyl)-3-[5- [[5-(1-hydroxy-2- methylpropan-2- yl)oxypyridin-2- yl]amino]-1-methyl-6- oxopyridazin-3- yl]phenyl]-1- oxoisoquinolin-6-yl]- 2-methylpropanenitrile::US9663494, Compound 2

SMILES Cn1nc(cc(Nc2ccc(OC(C)(C)CO)cn2)c1=O)-c1cccc(c1CO)-n1ccc2cc(cc(F)c2c1=O)C(C)(C)C#N

InChI Key InChIKey=CWQZQRJSBSNPQP-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 327854   

TargetTyrosine-protein kinase BTK(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM327854(2-[8-fluoro-2-[2- (hydroxymethyl)-3-[5- [[5-(1-hyd...)
Affinity DataIC50: 1.12nMAssay Description:The assay is a capture of radioactive 33P phosphorylated product through filtration. The interactions of BTK, biotinylated SH2 peptide substrate (Src...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/4/2019
Entry Details
US Patent