BDBM327981 (R)-N-(1-(4- cyanobenzyl)pyrrolidin- 3-yl)-5-(4-(4- fluorobenzyl)piperazine- 1-carbonyl)picolinamide::US10377742, Compound 118::US9663496, Compound 118

SMILES Fc1ccc(CN2CCN(CC2)C(=O)c2ccc(nc2)C(=O)N[C@@H]2CCN(Cc3ccc(cc3)C#N)C2)cc1

InChI Key InChIKey=ZTMNZDLYLCMZAQ-UHFFFAOYSA-N

Data  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 327981   

Target5'-AMP-activated protein kinase catalytic subunit alpha-2(Human)
Rigel Pharmaceuticals

US Patent
LigandPNGBDBM327981(US9663496, Compound 118 | (R)-N-(1-(4- cyanobenzyl...)
Affinity DataEC50: <500nMAssay Description:Compounds were assayed for their ability to activate AMPK using an enzyme-linked immunosorbent assay. Reagents and procedures for measuring AMPK acti...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/6/2020
Entry Details
US Patent

Target5'-AMP-activated protein kinase catalytic subunit alpha-2(Human)
Rigel Pharmaceuticals

US Patent
LigandPNGBDBM327981(US9663496, Compound 118 | (R)-N-(1-(4- cyanobenzyl...)
Affinity DataEC50: <500nMAssay Description:Compounds were assayed for their ability to activate AMPK using an enzyme-linked immunosorbent assay. Reagents and procedures for measuring AMPK acti...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/4/2019
Entry Details
US Patent