BDBM329361 US9663510, Example comparitive example 4

SMILES COc1cc(ccc1Nc1nc2ccc(cn2n1)-c1ccc(NC(=O)C2(CC2)c2ccc(F)cc2)cc1)S(C)(=O)=O

InChI Key InChIKey=BGGBSYYSDYIPKK-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 329361   

TargetDual specificity protein kinase TTK(Human)
Bayer Pharma Aktiengesellschaft

US Patent
LigandPNGBDBM329361(US9663510, Example comparitive example 4)
Affinity DataIC50: 15nMAssay Description:For the assay 50 nl of a 100-fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384 well microtiter plate (...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/4/2019
Entry Details
US Patent

TargetDual specificity protein kinase TTK(Human)
Bayer Pharma Aktiengesellschaft

US Patent
LigandPNGBDBM329361(US9663510, Example comparitive example 4)
Affinity DataIC50: 6.17E+3nMAssay Description:Inhibition of MPS1 in human HeLa cells assessed as reduction in spindle assembly checkpoint incubated for 4 hrs by p-histone H3/Hoechst 33342 stainin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetDual specificity protein kinase TTK(Human)
Bayer Pharma Aktiengesellschaft

US Patent
LigandPNGBDBM329361(US9663510, Example comparitive example 4)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of GST-tagged recombinant human MPS1 expressed in baculovirus expression system using biotin-Ahx-PWDPDDADITEILG as substrate preincubated ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed