BDBM330358 1-Cyclopentyl-1-(3-{[(3R,6R)-6-methyl-1-{[2-(2H-1,2,3-triazol-2-yl)phenyl]carbonyl}-piperidin-3-yl]oxy}phenyl)ethanol::US9725434, 16

SMILES C[C@@H]1CC[C@H](CN1C(=O)c1ccccc1-n1nccn1)Oc1cccc(c1)C(C)(O)C1CCCC1

InChI Key InChIKey=XJLCCMGDDJNAPQ-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 330358   

TargetOrexin receptor type 2(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM330358(US9725434, 16 | 1-Cyclopentyl-1-(3-{[(3R,6R)-6-met...)
Affinity DataIC50: 86nMAssay Description:The following table shows representative data for the compounds of the Examples as orexin receptor antagonists as determined by the FLIPR Ca2+ Flux A...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/12/2019
Entry Details
US Patent

TargetOrexin/Hypocretin receptor type 1(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM330358(US9725434, 16 | 1-Cyclopentyl-1-(3-{[(3R,6R)-6-met...)
Affinity DataIC50: 3.42E+3nMAssay Description:The following table shows representative data for the compounds of the Examples as orexin receptor antagonists as determined by the FLIPR Ca2+ Flux A...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/12/2019
Entry Details
US Patent