BDBM330367 (1S)-4- {[(3R,6R)-6- Methyl-1-{[2- (2H-1,2,3- triazol-2-yl) phenyl] carbonyl} piperidin-3-yl] oxy}-2,3-dihydro-1H- inden-1-ol::US9725434, 26

SMILES C[C@@H]1CC[C@H](CN1C(=O)c1ccccc1-n1nccn1)Oc1cccc2[C@@H](O)CCc12

InChI Key InChIKey=AVHBBFQHHMXHGS-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 330367   

TargetOrexin receptor type 2(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM330367(US9725434, 26 | (1S)-4- {[(3R,6R)-6- Methyl-1-{[2-...)
Affinity DataIC50: 25nMAssay Description:The following table shows representative data for the compounds of the Examples as orexin receptor antagonists as determined by the FLIPR Ca2+ Flux A...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/12/2019
Entry Details
US Patent

TargetOrexin/Hypocretin receptor type 1(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM330367(US9725434, 26 | (1S)-4- {[(3R,6R)-6- Methyl-1-{[2-...)
Affinity DataIC50: 1.53E+3nMAssay Description:The following table shows representative data for the compounds of the Examples as orexin receptor antagonists as determined by the FLIPR Ca2+ Flux A...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/12/2019
Entry Details
US Patent