BDBM330404 (S)—N6-(1-acryloylpyrrolidin-3-yl)-N4-(3-chloro-4-fluorophenyl)-7-(tetrahydrofuran-3-yloxy)quinazoline-4,6-diamine::US9725439, 6

SMILES Fc1ccc(Nc2ncnc3cc(O[C@H]4CCOC4)c(NC4CCN(C4)C(=O)C=C)cc23)cc1Cl

InChI Key InChIKey=HLFODSRWVVRNJJ-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 330404   

TargetEpidermal growth factor receptor [T790M,L858R](Human)
Chia Tai Tianqing Pharmaceutical Group

US Patent
LigandPNGBDBM330404(US9725439, 6 | (S)—N6-(1-acryloylpyrrolidin-3...)
Affinity DataIC50: 52.1nMAssay Description:EGFR, EGFR (T790M, L858R), HER2 kinase were expressed and purified through an insect cell expression system by the Department of Biology, Centaurus B...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/12/2019
Entry Details
US Patent