BDBM330405 1-(4-(4-(3-chloro-4-(3-fluorobenzyloxy)phenylamino)-7-methoxyquinazoline-6-ylamino)piperidin-1-yl)prop-2-ene-1-one::US9725439, 7

SMILES COc1cc2ncnc(Nc3ccc(OCc4cccc(F)c4)c(Cl)c3)c2cc1NC1CCN(CC1)C(=O)C=C

InChI Key InChIKey=CVFOZZUCRDVXIC-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 330405   

TargetEpidermal growth factor receptor [T790M,L858R](Human)
Chia Tai Tianqing Pharmaceutical Group

US Patent
LigandPNGBDBM330405(US9725439, 7 | 1-(4-(4-(3-chloro-4-(3-fluorobenzyl...)
Affinity DataIC50: 36.7nMAssay Description:EGFR, EGFR (T790M, L858R), HER2 kinase were expressed and purified through an insect cell expression system by the Department of Biology, Centaurus B...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/12/2019
Entry Details
US Patent