BDBM330411 N4-(3-acetylphenyl)-N6-(1-acryloylazetidin-3-yl)-7-methoxyquinazoline-4,6-diamine::US9725439, 13

SMILES COc1cc2ncnc(Nc3cccc(c3)C(C)=O)c2cc1NC1CN(C1)C(=O)C=C

InChI Key InChIKey=WIRGZYXZMXHDLS-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 330411   

TargetEpidermal growth factor receptor(Human)
Chia Tai Tianqing Pharmaceutical Group

US Patent
LigandPNGBDBM330411(US9725439, 13 | N4-(3-acetylphenyl)-N6-(1-acryloy...)
Affinity DataIC50: 0.100nMAssay Description:EGFR, EGFR (T790M, L858R), HER2 kinase were expressed and purified through an insect cell expression system by the Department of Biology, Centaurus B...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/12/2019
Entry Details
US Patent

TargetEpidermal growth factor receptor [T790M,L858R](Human)
Chia Tai Tianqing Pharmaceutical Group

US Patent
LigandPNGBDBM330411(US9725439, 13 | N4-(3-acetylphenyl)-N6-(1-acryloy...)
Affinity DataIC50: 5.30nMAssay Description:EGFR, EGFR (T790M, L858R), HER2 kinase were expressed and purified through an insect cell expression system by the Department of Biology, Centaurus B...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/12/2019
Entry Details
US Patent