BDBM330416 N6-(1-acryloylazetidin-3-yl)-N4-(3-chloro-4-fluorophenyl)-7-(2-morpholinylethoxy) quinazoline-4,6-diamine ::US9725439, 18

SMILES Fc1ccc(Nc2ncnc3cc(OCCN4CCOCC4)c(NC4CN(C4)C(=O)C=C)cc23)cc1Cl

InChI Key InChIKey=PNVPNZRZKSKFLG-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 330416   

TargetEpidermal growth factor receptor [T790M,L858R](Human)
Chia Tai Tianqing Pharmaceutical Group

US Patent
LigandPNGBDBM330416(US9725439, 18 | N6-(1-acryloylazetidin-3-yl)-N4-(3...)
Affinity DataIC50: 11.1nMAssay Description:EGFR, EGFR (T790M, L858R), HER2 kinase were expressed and purified through an insect cell expression system by the Department of Biology, Centaurus B...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/12/2019
Entry Details
US Patent