BDBM330417 6-(1-acryloylazetidin-3-yl)thio-N-(3-chloro-4-fluorophenyl)-7-methoxyquinazoline-4-amine ::US9725439, 19

SMILES COc1cc2ncnc(Nc3ccc(F)c(Cl)c3)c2cc1SC1CN(C1)C(=O)C=C

InChI Key InChIKey=QTPDNEFBIKGJSB-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 330417   

TargetEpidermal growth factor receptor(Human)
Chia Tai Tianqing Pharmaceutical Group

US Patent
LigandPNGBDBM330417(US9725439, 19 | 6-(1-acryloylazetidin-3-yl)thio-N-...)
Affinity DataIC50: 0.400nMAssay Description:EGFR, EGFR (T790M, L858R), HER2 kinase were expressed and purified through an insect cell expression system by the Department of Biology, Centaurus B...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/12/2019
Entry Details
US Patent

TargetEpidermal growth factor receptor [T790M,L858R](Human)
Chia Tai Tianqing Pharmaceutical Group

US Patent
LigandPNGBDBM330417(US9725439, 19 | 6-(1-acryloylazetidin-3-yl)thio-N-...)
Affinity DataIC50: 11.7nMAssay Description:EGFR, EGFR (T790M, L858R), HER2 kinase were expressed and purified through an insect cell expression system by the Department of Biology, Centaurus B...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/12/2019
Entry Details
US Patent