BDBM331155 1-benzenesulfonyl-3-[5-(1-methyl-1H-pyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl]-1H-pyrrolo[2,3-c]pyridine::US9725446, Compound A14

SMILES Cn1cc(cn1)-c1cnc2[nH]cc(-c3cn(c4cnccc34)S(=O)(=O)c3ccccc3)c2c1

InChI Key InChIKey=WGLOAYNMZIWPCF-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 331155   

LigandPNGBDBM331155(1-benzenesulfonyl-3-[5-(1-methyl-1H-pyrazol-4-yl)-...)
Affinity DataIC50: 1.00E+3nMAssay Description:The kinase assay is performed as 384-well flashplate assay.1 nM IKKε, 800 nM biotinylated IκBα(19-42) peptide (biotin-C6-C6-GLKKERLLDD...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/12/2019
Entry Details
US Patent

TargetSerine/threonine-protein kinase TBK1(Human)
Merck Patent

US Patent
LigandPNGBDBM331155(1-benzenesulfonyl-3-[5-(1-methyl-1H-pyrazol-4-yl)-...)
Affinity DataIC50: 1.00E+3nMAssay Description:The kinase assay is performed as 384-well flashplate assay.0.6 nM TANK binding kinase (TBK1), 800 nM biotinylated MELK-derived peptide (biotin-Ah-Ah-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/12/2019
Entry Details
US Patent

Target3-phosphoinositide-dependent protein kinase 1(Human)
Merck Patent

US Patent
LigandPNGBDBM331155(1-benzenesulfonyl-3-[5-(1-methyl-1H-pyrazol-4-yl)-...)
Affinity DataIC50: 5.50E+3nMAssay Description:The experimental batches are carried out in a flashplate system with 384 wells/microtitration plate.In each case, the PDK1 sample His6-PDK1 (1-50)(3....More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/12/2019
Entry Details
US Patent