BDBM331162 4-(1H-pyrrolo[2,3-b]pyridin-3-yl)-2,7-naphthyridin-1-ylamine ::US9725446, Compound A24

SMILES Nc1ncc(-c2c[nH]c3ncccc23)c2ccncc12

InChI Key InChIKey=AKIVVGUYCMQJHZ-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 331162   

TargetTGF-beta receptor type-1(Human)
Merck Patent

US Patent
LigandPNGBDBM331162(4-(1H-pyrrolo[2,3-b]pyridin-3-yl)-2,7-naphthyridin...)
Affinity DataIC50: 1.00E+3nMAssay Description:In-Vitro (Enzyme) Assay for Determination of the Efficacy of the Inhibitors of the Inhibition of TGF-Beta-Mediated EffectsAs an example, the ability ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/12/2019
Entry Details
US Patent

TargetSerine/threonine-protein kinase TBK1(Human)
Merck Patent

US Patent
LigandPNGBDBM331162(4-(1H-pyrrolo[2,3-b]pyridin-3-yl)-2,7-naphthyridin...)
Affinity DataIC50: 5.50E+3nMAssay Description:The kinase assay is performed as 384-well flashplate assay.0.6 nM TANK binding kinase (TBK1), 800 nM biotinylated MELK-derived peptide (biotin-Ah-Ah-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/12/2019
Entry Details
US Patent