BDBM331520 2-{11-[4-(2H3)Methyl-1-methyl-1H-1,2,3-triazol-5-yl]-8-[(S)-(oxan-4-yl)(phenyl)methyl]-3,8,12-triazatricyclo[7.4.0.02,7]trideca-1::BDBM331524::US9725449, Example 364

SMILES Cc1nnn(C)c1-c1cc2n([C@@H](C3CCOCC3)c3ccccc3)c3cc(cnc3c2cn1)C(C)(C)O

InChI Key InChIKey=GUESIHAGQSIQQN-MUUNZHRXSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 331520   

TargetBromodomain-containing protein 4 [1-477]/[333-460]/[44-168]/[44-460](Homo sapiens (Human))
Bristol-Myers Squibb

US Patent
LigandPNGBDBM331520(2-{11-[4-(2H3)Methyl-1-methyl-1H-1,2,3-triazol-5-y...)
Affinity DataIC50: <10nMAssay Description:The binding of compounds to bromodomain BRD4 (44-168), BRD4 (333-460), and BRD4 (1-477 or 44-460) was assessed using a time resolved fluorescent reso...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMyc proto-oncogene protein(Homo sapiens (Human))
Bristol Myers Squibb Research And Development

Curated by ChEMBL
LigandPNGBDBM331520(2-{11-[4-(2H3)Methyl-1-methyl-1H-1,2,3-triazol-5-y...)
Affinity DataIC50:  6.90nMAssay Description:Inhibition of c-MYC (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetBromodomain-containing protein 4 [1-477]/[333-460]/[44-168]/[44-460](Homo sapiens (Human))
Bristol-Myers Squibb

US Patent
LigandPNGBDBM331520(2-{11-[4-(2H3)Methyl-1-methyl-1H-1,2,3-triazol-5-y...)
Affinity DataIC50: <10nMAssay Description:The binding of compounds to bromodomain BRD4 (44-168), BRD4 (333-460), and BRD4 (1-477 or 44-460) was assessed using a time resolved fluorescent reso...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent