BDBM33234 thieno[2,3-d]pyrimidine, 34a

SMILES CCNC(=O)c1cc2c(nc(N)nc2s1)-c1cc(OCCN(CC)CC)c(Cl)cc1Cl

InChI Key InChIKey=KQRDVNUCOWRFLN-UHFFFAOYSA-N

Data  1 KI  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 33234   

TargetHeat shock protein HSP 90-alpha(Human)
University of Bologna

Curated by ChEMBL
LigandPNGBDBM33234(thieno[2,3-d]pyrimidine, 34a)
Affinity DataKi:  42nMAssay Description:Displacement of 2-[4-(2-Chloro-5-hydroxy-4-methoxy-phenyl)-5-cyano-7Hpyrrolo[2,3-d]pyrimidin-2-ylsulfanyl]-N-(2,2,2-trifluoroethyl)-acetamide spy lig...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
TargetHeat shock protein HSP 90-beta(Human)
Vernalis (R&D)

LigandPNGBDBM33234(thieno[2,3-d]pyrimidine, 34a)
Affinity DataIC50: 56nMpH: 7.4 T: 2°CAssay Description:The assay is based upon displacement of a fluorescently labeled molecule, which binds specifically to the ATP-binding site of full-length human Hsp90...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/26/2009
Entry Details Article
PubMed
TargetHeat shock protein HSP 90-alpha(Human)
University of Bologna

Curated by ChEMBL
LigandPNGBDBM33234(thieno[2,3-d]pyrimidine, 34a)
Affinity DataIC50: 56nMAssay Description:Inhibition of N-terminal human Hsp90-alpha ATP binding domain (2 to 236 residues) overexpressed in HEK293T cell lysate by fluorescence polarization a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed