BDBM332468 4-(1-(2-chloro- 6-(trifluoromethyl) benzoyl)-6-(oxazole-2- carbonyl)-1H- pyrazolo[4,3- b]pyridin-3-yl)- 3-fluorobenzoic acid::US10196354, Example 8D::US9745265, 8D

SMILES OC(=O)c1ccc(-c2nn(C(=O)c3c(Cl)cccc3C(F)(F)F)c3cc(cnc23)C(=O)c2ncco2)c(F)c1

InChI Key InChIKey=NTVUUWMYIXCQPR-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 332468   

TargetNuclear receptor ROR-gamma(Mouse)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM332468(US10196354, Example 8D | 4-(1-(2-chloro- 6-(triflu...)
Affinity DataIC50: 57nMAssay Description:To identify novel antagonists of RORgammaT, an assay was developed which employs the interaction of RORgammaT with its co-activator peptide SRC1_2. T...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/5/2019
Entry Details
US Patent

TargetNuclear receptor ROR-gamma(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM332468(US10196354, Example 8D | 4-(1-(2-chloro- 6-(triflu...)
Affinity DataIC50: 57nMAssay Description:The compounds of the invention inhibit RORgammaT activity. Activation of RORgammaT activity can be measured using, e.g., biochemical TR-FRET assay. I...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2019
Entry Details
US Patent