BDBM332477 4-(1-(2-chloro-6-(trifluoromethyl)benzoyl)-6-(1-methyl-1H-imidazol-4-yl)-1H-indazol-3-yl)-3-fluorobenzoic acid (17A)::US10196354, Example 17A::US9745265, 17A

SMILES Cn1cnc(c1)-c1ccc2c(nn(C(=O)c3c(Cl)cccc3C(F)(F)F)c2c1)-c1ccc(cc1F)C(O)=O

InChI Key InChIKey=FLOCZDVOIMRSCY-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 332477   

TargetNuclear receptor ROR-gamma(Mouse)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM332477(US10196354, Example 17A | 4-(1-(2-chloro-6-(triflu...)
Affinity DataIC50: 12nMAssay Description:To identify novel antagonists of RORgammaT, an assay was developed which employs the interaction of RORgammaT with its co-activator peptide SRC1_2. T...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/5/2019
Entry Details
US Patent

TargetNuclear receptor ROR-gamma(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM332477(US10196354, Example 17A | 4-(1-(2-chloro-6-(triflu...)
Affinity DataIC50: 12nMAssay Description:The compounds of the invention inhibit RORgammaT activity. Activation of RORgammaT activity can be measured using, e.g., biochemical TR-FRET assay. I...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2019
Entry Details
US Patent