BDBM332764 Cis-(chiral)-3-Chloro-N-[2- [5-(1,4-dimethyl-1H- imidazol-5-yl)-4H-1,2,4- triazol-3-yl]tetrahydro-2H- pyran-4-yl]-N-methyl- benzamide, Isomer 1::US10196385, Example 3

SMILES CN([C@@H]1CCO[C@@H](C1)c1nnc([nH]1)-c1c(C)ncn1C)C(=O)c1cccc(Cl)c1

InChI Key

Data  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 332764   

TargetProbable G-protein coupled receptor 142(Homo sapiens (Human))
Lilly China Research and Development Center (Lcrdc)

Curated by ChEMBL
LigandPNGBDBM332764(Cis-(chiral)-3-Chloro-N-[2- [5-(1,4-dimethyl-1H- i...)
Affinity DataEC50:  27nMAssay Description:Agonist activity at human GPR142 receptor expressed in HEK293 cells assessed as accumulation of inositol phosphate incubated for 1 hr followed by IP1...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProbable G-protein coupled receptor 142(Homo sapiens (Human))
Lilly China Research and Development Center (Lcrdc)

Curated by ChEMBL
LigandPNGBDBM332764(Cis-(chiral)-3-Chloro-N-[2- [5-(1,4-dimethyl-1H- i...)
Affinity DataEC50:  27.2nMAssay Description:HEK293 cells expressing human GPR142 are maintained in DMEM supplemented with 10% FBS and 800 μg/ml G418 (Geneticin) at 37° C. and 5% CO2. The c...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent