BDBM333453 US9737525, Compound MIND4

SMILES [O-][N+](=O)c1ccc(Sc2nnc(COc3ccccc3)n2-c2ccccc2)c2ncccc12

InChI Key InChIKey=RVYWJVIYWKCDEE-UHFFFAOYSA-N

Data  3 IC50  3 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 333453   

TargetNAD-dependent protein deacetylase sirtuin-2(Human)
The General Hospital

US Patent
LigandPNGBDBM333453(US9737525, Compound MIND4)
Affinity DataIC50:  1.70E+3nMAssay Description:Modulation of sirtuin activity by compounds was assessed using the Flour de Lys fluorescent biochemical assay in a 96-well format as described (Outei...More data for this Ligand-Target Pair
In DepthDetails US Patent

TargetNAD-dependent protein deacetylase sirtuin-2(Human)
The General Hospital

US Patent
LigandPNGBDBM333453(US9737525, Compound MIND4)
Affinity DataIC50:  3.50E+3nMAssay Description:Modulation of sirtuin activity by compounds was assessed using the Flour de Lys fluorescent biochemical assay in a 96-well format as described (Outei...More data for this Ligand-Target Pair
In DepthDetails US Patent

TargetNAD-dependent protein deacetylase sirtuin-2(Human)
The General Hospital

US Patent
LigandPNGBDBM333453(US9737525, Compound MIND4)
Affinity DataIC50:  1.20E+3nMAssay Description:Inhibition of Phosphodiesterase 2 from pig coronary arteryMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetKelch-like ECH-associated protein 1(Human)
University of Copenhagen

Curated by ChEMBL
LigandPNGBDBM333453(US9737525, Compound MIND4)
Affinity DataKd:  2.28E+4nMAssay Description:Binding affinity to KEAP1 (unknown origin) expressed in baculovirus expression system by surface plasmon resonance analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKelch-like ECH-associated protein 1(Human)
University of Copenhagen

Curated by ChEMBL
LigandPNGBDBM333453(US9737525, Compound MIND4)
Affinity DataKd: >3.00E+5nMAssay Description:Binding affinity to recombinant human KEAP1 Kelch domain (321 to 609 residues) expressed in Escherichia coli BL21 (DE3) by surface plasmon resonance ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKelch-like ECH-associated protein 1(Human)
University of Copenhagen

Curated by ChEMBL
LigandPNGBDBM333453(US9737525, Compound MIND4)
Affinity DataKd:  2.28E+4nMAssay Description:Binding affinity to recombinant human Keap1 by SPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed