BDBM334290 US9732061, Compound 12

SMILES OC(=O)c1cccc(CN2CCC(CC2)Nc2cnnc3ccc(cc23)C(c2ccc(Cl)cc2)c2ccc(Cl)cc2)c1

InChI Key InChIKey=ZXOXMKJRLZQGJE-UHFFFAOYSA-N

Data  4 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 334290   

TargetCannabinoid receptor 1(Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM334290(US9732061, Compound 12)
Affinity DataEC50:  302nMAssay Description:The following mixtures and buffer solutions were prepared: (a) Buffer 1: HBSS (Mediatech Cat#21-023-CV) with 5 mM HEPES (1 mM stock, Gibco BRL Cat#15...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2019
Entry Details
US Patent

TargetCannabinoid receptor 1(Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM334290(US9732061, Compound 12)
Affinity DataEC50:  302nMAssay Description:Inverse agonist activity at human CB1 receptor expressed in HEK293 cells assessed as forskolin-stimulated cAMP accumulation measured after 30 mins by...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details Article
PubMed
TargetCannabinoid receptor 2(Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM334290(US9732061, Compound 12)
Affinity DataEC50:  6.50E+3nMAssay Description:The following mixtures and buffer solutions were prepared: (a) Buffer 1: HBSS (Mediatech Cat#21-023-CV) with 5 mM HEPES (1 mM stock, Gibco BRL Cat#15...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2019
Entry Details
US Patent

TargetCannabinoid receptor 2(Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM334290(US9732061, Compound 12)
Affinity DataEC50:  6.50E+3nMAssay Description:Inverse agonist activity at human CB2 receptor expressed in HEK293 cells assessed as forskolin-stimulated cAMP accumulation measured after 30 mins by...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details Article
PubMed