BDBM335087 (4-Bromo-biphenyl-2-yl)-[(S)-2-methyl-2-(5-trifluoromethyl-1H-benzoimidazol-2-yl)-pyrrolidin-1-yl]-methanone::US11040966, Example 5.262::US9732075, Example 5.262

SMILES C[C@]1(CCCN1C(=O)c1cc(Br)ccc1-c1ccccc1)c1nc2cc(ccc2[nH]1)C(F)(F)F

InChI Key InChIKey=URIHGJROOMIUNL-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 335087   

TargetOrexin receptor type 2(Human)
Idorsia Pharmaceuticals

US Patent
LigandPNGBDBM335087(US9732075, Example 5.262 | (4-Bromo-biphenyl-2-yl)...)
Affinity DataIC50: 1nMAssay Description:Chinese hamster ovary (CHO) cells expressing the human orexin-1 receptor and the human orexin-2 receptor, respectively, are grown in culture medium (...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2019
Entry Details
US Patent

TargetOrexin/Hypocretin receptor type 1(Human)
Idorsia Pharmaceuticals

US Patent
LigandPNGBDBM335087(US9732075, Example 5.262 | (4-Bromo-biphenyl-2-yl)...)
Affinity DataIC50: 113nMAssay Description:Chinese hamster ovary (CHO) cells expressing the human orexin-1 receptor and the human orexin-2 receptor, respectively, are grown in culture medium (...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2019
Entry Details
US Patent