BDBM335275 US11040966, Example 6.47::US9732075, Example 6.47::[(S)-2-(4,5-Dimethyl-1H-benzoimidazol-2-yl)-4-methylene-pyrrolidin-1-yl]-[5-(3,4-dimethyl-phenyl)-2-methyl-thiazol-4-yl]-methanone

SMILES Cc1nc(C(=O)N2CC(=C)C[C@H]2c2nc3c(C)c(C)ccc3[nH]2)c(s1)-c1ccc(C)c(C)c1

InChI Key InChIKey=ZGXURSBUSGZSFT-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 335275   

TargetOrexin receptor type 2(Human)
Idorsia Pharmaceuticals

US Patent
LigandPNGBDBM335275(US9732075, Example 6.47 | [(S)-2-(4,5-Dimethyl-1H-...)
Affinity DataIC50: 1nMAssay Description:Chinese hamster ovary (CHO) cells expressing the human orexin-1 receptor and the human orexin-2 receptor, respectively, are grown in culture medium (...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2019
Entry Details
US Patent

TargetOrexin/Hypocretin receptor type 1(Human)
Idorsia Pharmaceuticals

US Patent
LigandPNGBDBM335275(US9732075, Example 6.47 | [(S)-2-(4,5-Dimethyl-1H-...)
Affinity DataIC50: 6nMAssay Description:Chinese hamster ovary (CHO) cells expressing the human orexin-1 receptor and the human orexin-2 receptor, respectively, are grown in culture medium (...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2019
Entry Details
US Patent