BDBM335745 (1-Amino-isoquinolin-6-ylmethyl)-{8-[4-(4-methyl-pyrazol-1-ylmethyl)-benzyl]-7,8-dihydro-6H-pyrimido[5,4-b][1,4]oxazin-4-yl}-amine::US9738641, 10

SMILES Cc1cnn(Cc2ccc(CN3CCOc4c(NCc5ccc6c(N)nccc6c5)ncnc34)cc2)c1

InChI Key InChIKey=QJAPXRXDBNITPR-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 335745   

TargetKallikrein-1(Human)
Kalvista Pharmaceuticals

US Patent
LigandPNGBDBM335745((1-Amino-isoquinolin-6-ylmethyl)-{8-[4-(4-methyl-p...)
Affinity DataIC50: 5.04E+3nMAssay Description:KLK1 inhibitory activity in vitro was determined using standard published methods (see e.g. Johansen et al., Int. J. Tiss. Reac. 1986, 8, 185; Shori ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/1/2019
Entry Details
US Patent

TargetPlasma kallikrein(Human)
Kalvista Pharmaceuticals

US Patent
LigandPNGBDBM335745((1-Amino-isoquinolin-6-ylmethyl)-{8-[4-(4-methyl-p...)
Affinity DataIC50: 2.05E+4nMAssay Description:Plasma kallikrein inhibitory activity in vitro was determined using standard published methods (see e.g. Johansen et al., Int. J. Tiss. Reac. 1986, 8...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/1/2019
Entry Details
US Patent