BDBM336532 US9745283, Example 5

SMILES COc1cc2nccc(Oc3ccc(NC(=O)c4cn(C(C)C)c(=O)n(-c5ccc(F)cc5)c4=O)cc3F)c2cc1OC

InChI Key InChIKey=FKCWHHYUMFGOPY-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 336532   

TargetTyrosine-protein kinase receptor UFO(Human)
University of South China

Curated by ChEMBL
LigandPNGBDBM336532(US9745283, Example 5)
Affinity DataIC50: 7nMAssay Description:Inhibition of AXL (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetTyrosine-protein kinase receptor UFO(Human)
University of South China

Curated by ChEMBL
LigandPNGBDBM336532(US9745283, Example 5)
Affinity DataIC50: 10nMAssay Description:The ability of compounds to inhibit the kinase activity of recombinant human baculovirus-expressed AXL was measured by homogeneous TRF (HTRF) using C...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/5/2019
Entry Details
US Patent

TargetHepatocyte growth factor receptor(Human)
University of South China

Curated by ChEMBL
LigandPNGBDBM336532(US9745283, Example 5)
Affinity DataIC50: 12nMAssay Description:Inhibition of c-MET (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetHepatocyte growth factor receptor(Human)
University of South China

Curated by ChEMBL
LigandPNGBDBM336532(US9745283, Example 5)
Affinity DataIC50: 55nMAssay Description:The cMET kinase assay was performed in 384-well Fluotrac 200 HiBase microplates using the HTRF KinEASE assay described above for AXL except that the ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/5/2019
Entry Details
US Patent