BDBM337684 3-[2-Methyl-3-(trifluoromethyl)benzyl]-2,4-dioxo-1-[4-(2-oxo-2,3-dihydro-1H-imidazol-1-yl)phenyl]-1,2,3,4-tetrahydropyrimidine-5-carboxylic acid::US9751843, 59

SMILES Cc1c(Cn2c(=O)c(C(=O)O)cn(-c3ccc(-n4cc[nH]c4=O)cc3)c2=O)cccc1C(F)(F)F

InChI Key InChIKey=WHDBXLUEIQLPLV-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 337684   

TargetChymase(Human)
Bayer AG

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 337684BDBM337684(3-[2-Methyl-3-(trifluoromethyl)benzyl]-2,4-dioxo-1...)
Affinity DataIC50: 42nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/5/2026
Entry Details PubMed
TargetChymase(Human)
Bayer AG

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 337684BDBM337684(3-[2-Methyl-3-(trifluoromethyl)benzyl]-2,4-dioxo-1...)
Affinity DataIC50: 217nMAssay Description:The enzyme source used is recombinant human chymase (expressed in HEK293 cells) or chymase purified from hamsters' tongues. The substrate used fo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/11/2019
Entry Details
US Patent

TargetChymase(Canis lupus familiaris)
Bayer AG

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 337684BDBM337684(3-[2-Methyl-3-(trifluoromethyl)benzyl]-2,4-dioxo-1...)
Affinity DataIC50: 760nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/5/2026
Entry Details PubMed