BDBM338724 3-(trans-2-((2,2- dimethylpropyl)amino)- cyclopropyl)-N-(5-methyl- 1,3,4-thiadiazol-2- yl)benzamide dihydrochloride::US9751885, 158

SMILES Cc1nnc(NC(=O)c2cccc(c2)C2CC2NCC(C)(C)C)s1

InChI Key InChIKey=QOBNKWRRXPTQJN-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 338724   

TargetLysine-specific histone demethylase 1A(Human)
Takeda Pharmaceutical

US Patent
LigandPNGBDBM338724(3-(trans-2-((2,2- dimethylpropyl)amino)- cycloprop...)
Affinity DataIC50: 100nMAssay Description:A test compound dissolved in 2.5% DMSO was added by 4 μL to 3 μL reaction solution (50 mM Tris-HCl (pH 8.0), 0.1% BSA, 1 mM DTT) containing...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/11/2019
Entry Details
US Patent

TargetAmine oxidase [flavin-containing] B(Human)
Takeda Pharmaceutical

US Patent
LigandPNGBDBM338724(3-(trans-2-((2,2- dimethylpropyl)amino)- cycloprop...)
Affinity DataIC50: 1.00E+4nMAssay Description:The MAO-B inhibitory activity evaluation described below followed the protocol of MAO-Glo (registered trademark) Assay of Promega KK.A test compound ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/11/2019
Entry Details
US Patent

TargetAmine oxidase [flavin-containing] A(Human)
Takeda Pharmaceutical

US Patent
LigandPNGBDBM338724(3-(trans-2-((2,2- dimethylpropyl)amino)- cycloprop...)
Affinity DataIC50: 1.00E+4nMAssay Description:A test compound dissolved in 4% DMSO was added by 12.5 μL to 25 μL reaction solution (100 mM HEPES (pH 7.5), 5% glycerol) containing 400 ng...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/11/2019
Entry Details
US Patent