BDBM339998 5-{[(3R,4R)-3- aminotetrahydro-2H-pyran-4- yl]amino}-3-(2,3-dihydro-7H- [1,4]dioxin[2,3-e]indol-8- yl)pyrazine-2-carboxamide::US9775839, 10.3

SMILES NC(=O)c1ncc(N[C@@H]2CCOC[C@@H]2N)nc1-c1cc2c3c(ccc2[nH]1)OCCO3

InChI Key InChIKey=WDZSUWIDWIHGJP-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 339998   

TargetTyrosine-protein kinase SYK(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 339998BDBM339998(5-{[(3R,4R)-3- aminotetrahydro-2H-pyran-4- yl]amin...)
Affinity DataIC50: 0.5nMAssay Description:A recombinant GST-hSYK fusion protein was used to measure potency of compounds to inhibit human Syk activity. The recombinant human GST-SYK (Carna Bi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/11/2019
Entry Details
US Patent