BDBM34059 brominated benzimidazole, 20

SMILES c1nc2c(n1CC(=O)O)c(c(c(c2Br)Br)Br)Br

InChI Key InChIKey=WIMPWBKZHKEQQS-UHFFFAOYSA-N

Data  5 KI

PDB links: 1 PDB ID matches this monomer.

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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 34059   

TargetCasein kinase II subunit alpha'(Human)
The John Paul Ii Catholic University of Lublin

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 34059BDBM34059(brominated benzimidazole, 20)
Affinity DataKi:  342nMAssay Description:Inhibition of human CK2 alpha' catalytic subunit expressed in Escherichia coli BE21 (DE3) assessed as [33P]gamma-ATP incorporation into RRRADDSDDDDD ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/21/2012
Entry Details Article
PubMed
TargetCasein kinase II subunit alpha'(Human)
The John Paul Ii Catholic University of Lublin

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 34059BDBM34059(brominated benzimidazole, 20)
Affinity DataKi:  609nMAssay Description:Inhibition of human CK2 alpha' catalytic subunit expressed in Escherichia coli BL21 (DE3) assessed as [33P]gamma-ATP incorporation into P2B substrate...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/21/2012
Entry Details Article
PubMed
TargetCasein kinase II subunit alpha(Human)
The John Paul Ii Catholic University of Lublin

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 34059BDBM34059(brominated benzimidazole, 20)
Affinity DataKi:  670nMAssay Description:Inhibition of human CK2 alpha catalytic subunit expressed in Escherichia coli BL21 (DE3) assessed as [33P]gamma-ATP incorporation into RRRADDSDDDDD s...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/21/2012
Entry Details Article
PubMed
TargetCasein kinase II subunit alpha(Human)
The John Paul Ii Catholic University of Lublin

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 34059BDBM34059(brominated benzimidazole, 20)
Affinity DataKi:  798nMAssay Description:Inhibition of human CK2 alpha catalytic subunit expressed in Escherichia coli BE21 (DE3) assessed as [33P]gamma-ATP incorporation into P2B substrate ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/21/2012
Entry Details Article
PubMed
TargetCasein kinase II subunit alpha(Rat)
University of Padova

LigandChemical structure of BindingDB Monomer ID 34059BDBM34059(brominated benzimidazole, 20)
Affinity DataKi:  1.34E+3nM ΔG°:  -8.33kcal/molepH: 7.5 T: 2°CAssay Description:Inhibitory effect of test compound was assessed in reaction buffer containing purified CK2, synthetic peptide substrate, and [gamma-33P]ATP. Assays w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/9/2009
Entry Details Article
PubMed