BDBM340996 N-(4-Hydroxyphenyl)-1-(6-{[(3S)-3-[(4-methylpiperazin-1-yl)methyl]-3,4-dihydroisoquinolin-2(1H)-yl]carbonyl}-1,3-benzodioxol-5-yl)-N-[4-(trifluoro-methoxy)phenyl]-1H-indole-3-carboxamide::US9765056, Example 51

SMILES CN1CCN(C[C@@H]2Cc3ccccc3CN2C(=O)c2cc3OCOc3cc2-n2cc(C(=O)N(c3ccc(O)cc3)c3ccc(OC(F)(F)F)cc3)c3ccccc23)CC1

InChI Key InChIKey=AEZHQEWJXKHVOG-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 340996   

TargetApoptosis regulator Bcl-2(Human)
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US Patent
LigandPNGBDBM340996(US9765056, Example 51 | N-(4-Hydroxyphenyl)-1-(6-{...)
Affinity DataIC50: 6.90nMAssay Description:Method A:The fluorescence polarisation tests were carried out on microplates (384 wells). The Bcl-2 protein, labelled (histag-Bcl-2 such that Bcl-2 c...More data for this Ligand-Target Pair
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Date in BDB:
7/29/2019
Entry Details
US Patent