BDBM341042 1-(5-Chloro-2-{[(3S)-3-[(dimethylamino)methyl]-3,4-dihydroisoquinolin-2(1H)-yl]carbonyl}phenyl)-N-(4-hydroxyphenyl)-5-methyl-N-(1-methyl-1H-indol-5-yl)-1H-pyrrole-3-carboxamide hydrochloride::US9765056, Example 95

SMILES CN(C)C[C@@H]1Cc2ccccc2CN1C(=O)c1ccc(Cl)cc1-n1cc(cc1C)C(=O)N(c1ccc(O)cc1)c1ccc2n(C)ccc2c1

InChI Key InChIKey=JJAAKVCLNQAKIF-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 341042   

TargetApoptosis regulator Bcl-2(Human)
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US Patent
LigandPNGBDBM341042(US9765056, Example 95 | 1-(5-Chloro-2-{[(3S)-3-[(d...)
Affinity DataIC50: 6.40nMAssay Description:Method A:The fluorescence polarisation tests were carried out on microplates (384 wells). The Bcl-2 protein, labelled (histag-Bcl-2 such that Bcl-2 c...More data for this Ligand-Target Pair
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Date in BDB:
7/29/2019
Entry Details
US Patent