BDBM341048 N-(4-Hydroxyphenyl)-1-(6-{[(3S)-3-[(4-methylpiperazin-1-yl)methyl]-3,4-dihydroisoquinolin-2(1H)-yl]carbonyl}-1,3-benzodioxol-5-yl)-N-[1-(propan-2-yl)-1H-indol-5-yl]-1H-indole-3-carboxamide::US9765056, Example 100

SMILES CC(C)n1ccc2cc(ccc12)N(C(=O)c1cn(-c2cc3OCOc3cc2C(=O)N2Cc3ccccc3C[C@H]2CN2CCN(C)CC2)c2ccccc12)c1ccc(O)cc1

InChI Key InChIKey=FRVFFKWAMIQYAW-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 341048   

TargetApoptosis regulator Bcl-2(Human)
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US Patent
LigandPNGBDBM341048(US9765056, Example 100 | N-(4-Hydroxyphenyl)-1-(6-...)
Affinity DataIC50: 6.90nMAssay Description:Method A:The fluorescence polarisation tests were carried out on microplates (384 wells). The Bcl-2 protein, labelled (histag-Bcl-2 such that Bcl-2 c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/29/2019
Entry Details
US Patent