BDBM341133 N-(4-Hydroxyphenyl)-1-{5-methoxy-2-[(3S)-3-[(4-methylpiperazin-1-yl)methyl]-1,2,3,4-tetrahydroisoquinoline-2-carbonyl]phenyl}-N-(1-methyl-1H-indol-5-yl)-1H-indole-3-carboxamide::US9765056, Example 205

SMILES COc1ccc(C(=O)N2Cc3ccccc3C[C@H]2CN2CCN(C)CC2)c(c1)-n1cc(C(=O)N(c2ccc(O)cc2)c2ccc3n(C)ccc3c2)c2ccccc12

InChI Key InChIKey=HJFQXVDCRGSXME-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 341133   

TargetApoptosis regulator Bcl-2(Human)
Les Laboratoires Servier

US Patent
LigandPNGBDBM341133(US9765056, Example 205 | N-(4-Hydroxyphenyl)-1-{5-...)
Affinity DataIC50: 4.30nMAssay Description:Method A:The fluorescence polarisation tests were carried out on microplates (384 wells). The Bcl-2 protein, labelled (histag-Bcl-2 such that Bcl-2 c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/29/2019
Entry Details
US Patent