BDBM344047 US10370387, Example 31::US11161855, Example 31::US9777017, Example 31

SMILES CCNC(=O)C[C@H]1CC[C@H](n2c([C@@H](C)O)nc3cnc4ccsc4c32)CC1

InChI Key InChIKey=MUSMDGKQBBDFFG-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 344047   

TargetTyrosine-protein kinase JAK1(Human)
Incyte Holdings

US Patent
LigandChemical structure of BindingDB Monomer ID 344047BDBM344047(US9777017, Example 31 | US10370387, Example 31 | U...)
Affinity DataIC50: 1.00E+3nMAssay Description:Compounds herein were tested for inhibitory activity of JAK targets according to the following in vitro assay described in Park et al., Analytical Bi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2019
Entry Details
US Patent

TargetTyrosine-protein kinase JAK1 [837-1142](Human)
Incyte

US Patent
LigandChemical structure of BindingDB Monomer ID 344047BDBM344047(US9777017, Example 31 | US10370387, Example 31 | U...)
Affinity DataIC50: 1.00E+3nMAssay Description:Compounds herein were tested for inhibitory activity of JAK targets according to the following in vitro assay described in Park et al., Analytical Bi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/20/2022
Entry Details
US Patent

TargetTyrosine-protein kinase JAK1 [837-1142](Human)
Incyte

US Patent
LigandChemical structure of BindingDB Monomer ID 344047BDBM344047(US9777017, Example 31 | US10370387, Example 31 | U...)
Affinity DataIC50: 1.00E+3nMAssay Description:Compounds herein were tested for inhibitory activity of JAK targets according to the following in vitro assay described in Park et al., Analytical Bi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/6/2020
Entry Details
US Patent

TargetTyrosine-protein kinase JAK2 [828-1132](Human)
Incyte

US Patent
LigandChemical structure of BindingDB Monomer ID 344047BDBM344047(US9777017, Example 31 | US10370387, Example 31 | U...)
Affinity DataIC50: 1.00E+4nMAssay Description:Compounds herein were tested for inhibitory activity of JAK targets according to the following in vitro assay described in Park et al., Analytical Bi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/20/2022
Entry Details
US Patent

TargetTyrosine-protein kinase JAK2(Human)
Incyte Holdings

US Patent
LigandChemical structure of BindingDB Monomer ID 344047BDBM344047(US9777017, Example 31 | US10370387, Example 31 | U...)
Affinity DataIC50: 2.00E+4nMAssay Description:Compounds herein were tested for inhibitory activity of JAK targets according to the following in vitro assay described in Park et al., Analytical Bi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2019
Entry Details
US Patent

TargetTyrosine-protein kinase JAK2 [828-1132](Human)
Incyte

US Patent
LigandChemical structure of BindingDB Monomer ID 344047BDBM344047(US9777017, Example 31 | US10370387, Example 31 | U...)
Affinity DataIC50: 5.00E+5nMAssay Description:Compounds herein were tested for inhibitory activity of JAK targets according to the following in vitro assay described in Park et al., Analytical Bi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/6/2020
Entry Details
US Patent